The first habitation of the site dates from the Neolithic and Early Minoan period (3rd millenium B.C.). In the late Classical period (beginning of the 4th century B.C.) the Gortynians established the sanctuary of Asklepios at the harbour. During the tremendous earthquake of 46 B.C. the city was destroyed and subsequently rebuilt. In the Early Christian and Byzantine periods, a small settlement developed and the basilica was erected. The most important monuments of the site are:
The Temple of Asklepios., the "Treasury"., the Fountain, a large, three-aisled basilica, an Early Minoan settlement (2600-2000 B.C.), the West Stoa, the North Stoa, the Nymphaion and two large, mud-brick cisterns.

Agios Thomás (GR: Αγιος Θωμάς) lies at 530 m above sea level. It is 30 km away from Heraklion and has a panoramic view over the whole area to the SE of Aghia Varvara.
Agios Thomas is a very old village and the first reference we have of it, is in a document of 1371, where it is quoted as a feudal property of Petrus de Medio, and again in a document dated 1380. Later, it figures in all the Venetian censi of the 16th and 17th centuries. In 1881, and in 1900, it figures as part of the Megali Vrisi municipality, with 344 inhabitants. From 1920, it figures in all the censi as a community with a continuously growing number of inhabitants. Nowadays there are over 800 inhabitants.

Anogia is a mountain town with 2500 permanent residents and is 55 km away from Rethymnon and 36 km from Iraklion. The name Anogia, means "high place - Ano Gi", is connected with the location that is built, in altitude of 700 m. Hospitable and pleasant residents have to tell a lot of old stories that have marked the tradition and the culture of the village. Anogia is a well-known village historically for its resident's resistance to the conquerors, Turkish and Germans.

The Holy Monastery of Preveli, to mark the occasion of the 60th anniversary of the Battle of Crete, decided to erect privately and under its supervision, an international memorial dedicated to the Resistance of the Cretan Population and Peace.
The Memorial was erected on the monastery's own land, on a site with a stunning panoramic view, overlooking the Libyan sea. The site is alongside the main bitumen road to the Monastery, and just 1.8 kms before the Monastery itself.

The Monastery of Arkádi (GR:Αρκάδι) built during the last Venetian period, it consists of a large set of fortress-like buildings. The main building included the cells, the warehouses where the agricultural products were treated and stored, the stables. In a word, it was a well-equipped little fortress where people could find refuge in times of trouble. There is an impressive church, with two naves dedicated to Saint Constantine and Saint Helen, and to Our Lord. Due to the holocaust it suffered in 1866, Arkadi has become the island's most famous monastery.

It stands 37 km south of Rethimnon, in an imposing landscape which is mentioned at the mid-19th century diary of Th. Spratt (admiral of the British Royal Navy), as "one of the happiest places to withdraw from trials and responsibilities of life".There are lots of legends concerning the foundation of the monastery, which is believed that started during the Venetian occupation of the island. A number of its monks activities made the monastery one of the richest of western Crete and due to its isolated position it played important role in Cretan revolts against the occupying forces. A substantial number of icons and other items is kept in the Museum of the Monastery of Preveli amongst them the miracle - working Eulogistic Cross of Efraim Prevelis.